SURVIVAL OUTCOMES AFTER WHOLE BRAIN RADIOTHERAPY

Abstract AIMS Cerebral metastases from extra-cranial primary cancer carries a poor prognosis. For patients in whom surgical resection or SRS are not suitable, local control rates poor. There is considerable debate surrounding the value of whole brain radiotherapy this patient cohort terms control, survival and functional status. We aimed to measure receiving at Norfolk Norwich University Hospital. METHOD All who completed course our centre between April 2018 December 2022 were retrospectively analysed. Patients prophylactic cranial irradiation small cell lung excluded. Baseline demographics, oncologist declared ECOG performance status referral for treatment, dose recorded. RESULTS 88 received WBRT during period. The median follow-up interval was 85 days. 12 30 Gy 10 fractions, 59 20 5 fractions 17 2 fractions. overall following completion At 6 weeks after radiotherapy, 23.9% had died. Univariate analysis with Cox proportional hazards model did demonstrate significant hazard ratio age (<65 ≥65), dose. CONCLUSIONS Survival remains In particular, almost quarter alive treatment. This particularly pertinent given anticipated trajectory acute toxicities